Figure 3.

Schematic of the microfluidic sonication method proposed by [41] to assemble biomimetic core-shell nanoparticles. (A) The microfluidic chip uses sonication and hydrodynamic mixing methods for the synthesis of exosome membrane (EM)-, cancer cell membrane (CCM)-, and lipid-coated nanoparticles. The precursors are injected into the chip from the inlets (1–4), and the product is collected from the outlet. (B) Reduced uptake of the produced biomimetic nanoparticles by the peripheral blood monocytes and extracellular matrix macrophages is shown. Reprinted with permission from C. Liu, et al., 2019 Nano Letters 19(11), 7836–7844 [41]. Copyright 2019 American Chemical Society.