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. 2021 Jul 7;22(14):7290. doi: 10.3390/ijms22147290

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of panobinostat on the expression of HDAC4, HDAC6, and HDAC7 in cartilage tissues. (A) Immunohistochemical staining of HDAC4, HDAC6, and HDAC7 in joint sections from the control, ACLT, ACLT + panobinostat (2 or 10 μg) groups. The immunoreactive positive cells are indicated in brown (arrows). Results from the quantitative analysis of the ratio of (B) HDAC4-, (C) HDAC6-, and (D) HDAC7-positive cells in joint sections are presented. Data are expressed as means ± SEM for each group. Scale bar represents 100 μm. HDAC, histone deacetylase; ACLT, anterior cruciate ligament transection; Pano, panobinostat; SEM, standard error of the mean. (* p < 0.05 vs. the control group; ^# p < 0.05 vs. the ACLT group).