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Composition of parenchyma. Representative light microscopic images of control (ctrl) and Nedd4-2-deficient lungs (Nedd4-2−/−) after 2, 8 and 12 weeks of doxycycline induction. At 12 weeks, septal walls appears thicker, and in some areas, lungs are consolidated by inflammatory infiltrates and fibrosis without recognizable acinar microarchitecture. Scale bar 200 µm.
