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. 2021 Jul 16;22(14):7607. doi: 10.3390/ijms22147607

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Composition of septal walls. Electron microscopic images of the ultrastructure of control (ctrl) and Nedd4-2 deficient lungs (Nedd4-2^−/−) after 2, 8 and 12 weeks of doxycycline induction. Increase of collagen fibrils, interstitial cells and alveolar epithelial type II (AE2) cells can be observed after 12 weeks. Abbreviations: AE1: alveolar epithelial type I cells; AE2: alveolar epithelial type II cells; LB: lamellar body; Endo: endothelial cells; IC: interstitial cells; _recm: extracellular matrix without collagen fibrils; col: collagen fibrils; capl: capillary lumen (with erythrocyte); bl: basal lamina.