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. 2021 Jul 16;22(14):7607. doi: 10.3390/ijms22147607

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Composition of the alveolar epithelium after 12 weeks. (A) Electron microscopic image of the ultrastructure of intermediate cells and AE2 cells in Nedd4-2-deficient lungs (Nedd4-2^−/−) after 12 weeks. Intermediate cells were only found after 12 weeks of Nedd4-2 deficiency. These cells contain a few lamellar bodies and form extensions similar to squamous epithelial cells so that they have properties of both AE1 and AE2 cells. Abbreviations: AE2: alveolar epithelial type II cells; IC: interstitial cells; col: collagen fibrils. (B) Surface fraction of the basal lamina (bl) covered by AE1 cells (AE1_bl), AE2 cells (AE2_bl) and intermediate cells (Inter_bl) in controls (ctrl) and Nedd4-2-deficient (Nedd4-2^−/−) lungs. There is a reduced surface area of the epithelial basal lamina covered by AE1 cells and a significantly increased surface area of the epithelial basal lamina covered by AE2 cells and intermediate cells. Data are provided as mean.