Figure 5.

Correlation between different structural data of Nedd4-2-deficient (Nedd4-2^−/−) lungs after 12 weeks. (A) The arithmetic mean thickness of the blood–gas barrier demonstrates a highly significant positive correlation with the fraction of surface area of basal lamina covered by AE2 cells and (B) a highly significant positive correlation with the volume-weighted mean volume of lamellar bodies. (C) The volume of collagen fibrils demonstrates no significant correlation with the fraction of surface area of basal lamina covered by AE2 cells and (D) a positive, highly significant correlation with the volume-weighted mean volume of lamellar bodies. (E) The volume of interstitial cells demonstrates a positive significant correlation with the fraction of surface area of basal lamina covered by AE2 cells and (F) a positive, highly significant correlation with the volume-weighted mean volume of lamellar bodies. The Spearman correlation coefficient r and statistical significance p are provided.