Table 1.
Lung architecture.
| Group | 2 Weeks | 8 Weeks | 12 Weeks | Two-Way ANOVA | |||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | ctrl | Nedd4-2−/− | ctrl | Nedd4-2 −/− | ctrl | Nedd4-2 −/− | G | T | Inter |
| Females/males | 4/2 | 3/3 | 3/3 | 3/3 | 4/2 | 3/3 | |||
| V(lung) cm³ | 0.59 (0.03) | 0.60 (0.05) | 0.64 (0.04) | 0.61 (0.05) | 0.80 (0.03) | 0.85 (0.06) | n.s. | <0.001 | 0.028 |
| V(par,lung) cm³ | 0.51 (0.04) | 0.51 (0.04) | 0.54 (0.03) | 0.51 (0.04) | 0.65 (0.03) | 0.68 (0.07) | n.s. | <0.001 | n.s. |
| V(sep,par) cm³ | 0.13 (0.02) | 0.12 (0.01) | 0.13 (0.01) | 0.16 (0.01) | 0.16 (0.02) | 0.22 (0.05) | 0.001 | <0.001 | 0.011 |
| V(air,par) cm³ | 0.38 (0.05) | 0.39 (0.03) | 0.40 (0.02) | 0.36 (0.04) | 0.49 (0.02) | 0.40 (0.09) | 0.016 | 0.004 | n.s. |
| V(cons,lung) cm³ | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.05 (0.03) | ––– | ––– | <0.001 |
Summarized light microscopic data are provided as mean (standard deviation). Parameters are defined in the text and in the methods section. Statistical analysis was based on a two-way ANOVA taking the factors genetics (G: ctrl vs. Nedd4-2−/−) and time (T: weeks) as well as the interaction (Inter) of these factors into account. p-values below 0.05 were considered as statistically significant. Abbreviations: V: volume; par: lung parenchyma; sep: interalveolar septa; air: acinar airspaces; cons: consolidated lung parenchyma.