Figure 2.

Diverse spheroids such as the breast models in a microfluidic chip. (A) Different cell spheroids of uniformly sized breast tumor cell of MCF-7 and fibroblast were prepared and systematic analyzed in a microfluidic device [12]. Open access. (B) Monocytes are co-cultured with low invasive low invasive T47D spheroids or high invasive MD-MBA-231 spheroids in a collagen matrix-embedded microfluidic device [17]. Reprinted with permission from ref. [17]. Copyright 2018 Chinese Academy of Medical Sciences. (C) A great number of uniform 3D tumor spheroids of breast cancer cell T47D were formed as well as other human cancer cell lines of HepG2 and HCT116 in a microfluidic chip for drug susceptibility testing [19]. Reprinted with permission from ref. [19]. Copyright 2015 Elsevier B.V.