Table 3.
The expression levels of potential miRNA-based biomarkers in cholangiocarcinoma.
| miRNA | Expression | Detectable Location | Tumor Type (Background) |
Biomarker Category | References |
|---|---|---|---|---|---|
| miR-21, miR-221 | Upregulated | Plasma | Hepatolithiasis-CCA | Diagnosis/Prognosis | [45,121] |
| miR-26a | Upregulated | Serum | CCA | Diagnosis/Prognosis | [128] |
| miR-150-5p | Downregulated | Serum | CCA | Diagnosis | [129] |
| miR-29a | Upregulated | Tissue | CCA | Prognosis | [130] |
| miR-192 | Upregulated | Serum | CCA | Prognosis | [131] |
| miR-151-3p | Upregulated | Tissue | Resected CCA | Prognosis | [132] |
| miR-126 | Downregulated | Tissue | Resected CCA | Prognosis | [132] |
| miR-106a | Downregulated | Serum | CCA | Prognosis | [133] |
| miR-146a | Upregulated | Tissue | iCCA | Prognosis | [134] |
| miR-31 | Upregulated | Tissue | CCA | Prognosis | [135] |
| miR-203 | Downregulated | Tissue | CCA | Prognosis | [136] |
| miR-191 | Upregulated | Tissue | iCCA | Prognosis | [85] |
| miR-195 | Downregulated | Serum | CCA | Prognosis | [137] |
| miR-16 | Downregulated | Plasma | dCCA | Diagnosis | [138] |
| miR-877 | Upregulated | Plasma | dCCA | Diagnosis | [138] |
Abbreviations: CCA, cholangiocarcinoma; iCCA, intrahepatic cholangiocarcinoma; dCCA distal cholangiocarcinoma.