Table 7.

Phenotypes observed in Huntington’s disease induced neural precursor cell-derived neurons.

Study	HD Line	Differentiation	Huntington’s Disease Phenotype
Hou et al. (2017) [133]	41 CAG (onset not reported) 41 CAG (onset not reported)	Subpopulation TUJ1+, GFAP+, GALC+	Increased γH2AX indicating DNA damage in embryonic-like progenitors Adenosine receptor agonist reversed phenotype
Monk et al. (2021) [134]	41 CAG (onset 56 years) 43 CAG (onset 50 years) 44 CAG (onset 33 years) 57 CAG (onset 27 years)	20% TUJ1+ (normal) 12% TUJ1+ (HD) 69% DARPP32+/TUJ1+ (normal) 54% DARPP32+/TUJ1+ (HD)	Ubiquitinated mHTT aggregates (57 CAG) Maintenance of transcriptional phenotype Significantly smaller cell soma areas Significantly shorter neurite length Significantly reduced neurite branching Significantly more depolarized RMPs Decreased BDNF protein correlated with reduced age of symptom onset and increased number of CAG repeats