Figure 3.

Repeated oxygen glucose deprivation (OGD) resulted in a steady impairment of synaptic transmission recovery in miRNA 132/212^−/− but not WT dentate gyri. Scatter plots depicting normalized fEPSP slope values at the normoxic, euglycemic baseline and the ends of the three recovery periods. (A) As revealed by within-subject analysis, fEPSP slopes recorded in slices obtained from miRNA 132/212^−/− mice (white filled inverted triangles) recovered to statistically significant lower values after OGD in comparison to each preceding recovery interval. (B) In contrast, in slices obtained from WT mice (white filled circles) within-subject analysis revealed statistically significant differences between fEPSP slope values reached at the first vs. the third recovery period, while values at the first vs. second and second vs. third recovery periods no longer differed significantly. Data is presented as mean ± SEM. fEPSP: field excitatory postsynaptic potential, OGD: Oxygen Glucose Deprivation. p < 0.05 was considered significant. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. ns: no statistical significance.