Table 1.

Slc DEGs encoding the transporters in different brain regions according to type of substrate category for every gene.

Substrate Category *	The Slc Transporters, Cotransporters, or Symporter Genes
	VTA	NAcc	PFC
Amino acids: glycine, proline, and glutamate, etc.	↓Slc38a10	↓Slc1a5, ↓Slc7a11, ↓Slc38a2,↓Slc38a11	↑Slc38a2
Glucose, nucleotide sugars	↓Slc5a11, ↓Slc35e1	↓Slc2a4, ↓Slc47a1	↓Slc35f4
Metals: zinc, magnesium, copper	↓Slc39a13	↓Slc31a1, ↓Slc41a1	↑Slc39a2
Neurotransmitters: noradrenaline, serotonin, glutamate, choline, GABA, proline	↑Slc6a2,↑Slc6a3 **, ↑Slc6a4	↓Slc5a7, ↓Slc6a12, ↓Slc6a13, ↓Slc6a20a	↓Slc6a7
Vesicular transporter of neurotransmitter glutamate, acetylcholine, GABA, glycine and amino acid	↑ Slc17a7, ↑Slc17a8, ↓Slc18a3, ↓Slc32a1,	↑ Slc17a7	↓Slc17a8
Inorganic ions: chloride, bicarbonate, hydroxide, sulfate, potassium, sodium, phosphate, monocarboxylate jodide, etc.	↓Slc12a4, ↓Slc12a9	↓Slc4a2, ↓Slc4a5, ↑Slc4a11, ↓Slc5a5, ↓Slc12a7, ↓Slc13a3, ↓Slc13a4, ↓Slc16a12	↓Slc5a5,↑Slc16a12,↑Slc16a13, ↓Slc26a4
Organic anions and cations, oligopeptide	↑Slc22a3, ↓Slco3a1	↓Slc22a2, ↓Slc22a6, ↓Slc22a8, ↓Slco5a1
Nucleosides	↓Slc28a3,↓Slc29a4	↓Slc29a4	↑Slc29a3
Mitochondria		↓Slc25a18	↑Slc25a47
Fatty acids	↓Slc27a1

Emphasized line: common genes for regions; Bold font: ↑upregulation; Regular font: ↓downregulation; * Substrate category for every gene was taken from [1,2,3], ** [17,19].