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. 2021 Jun 24;9(7):1375. doi: 10.3390/microorganisms9071375

Figure 4.

Figure 4

Dose response curves of peripheral blood mononuclear cells from four representative donors (n > 10); C 168-171 treated with S. sonnei GMMA (1790GAHB FF01) and Shigella four-component GMMA drug product (DP) and drug substance (DS). (a) Data show S. sonnei 1790 GMMA DS (pink sqaures), S. sonnei GMMA DP (1790GAHB FF01, black circles) and Shigella four-component GMMA DP (green triangles). The highest concentration of all Shigella GMMA vaccine products was 6.25 ng/mL for donors C169–171 and 1.56 ng/mL for donor C168. (b) Data show Shigella four-component DS (pink circles) and DP (black circles). The highest concentration of Shigella four-component GMMA DP and DS was 12.5 ng/mL for donors C169–171 and 1.56 ng/mL for donor C168.