Table 2.
The kinetic parameters of the first stage of the release of 5-ASA from F1–F5.
| Kinetic Model | Kinetic Parameters | F1 | F2 | F3 | F4 | F5 |
|---|---|---|---|---|---|---|
| Z-O | k0 [mg × min−1] | 4.7 ± 0.6 | 2.5 ± 0.3 | 6.2 ± 1.2 | 5.4 ± 0.8 | 5.4 ± 0.6 |
| t0.5 [min] | 58.8 ± 6.8 | 106.6 ± 13.7 | 44.3 ± 8.6 | 47.2 ± 7.0 | 46.2 ± 5.1 | |
| R2 | 0.96 ± 0.01 | 0.97 ± 0.02 | 0.92 ± 0.02 | 0.95 ± 0.02 | 0.97 ± 0.01 | |
| F-O | k1 × 102 [min−1] | 1.2 ± 0.2 | 0.5 ± 0.1 | 1.2 ± 0.4 | 1.3 ± 0.2 | 1.6 ± 0.2 |
| t0.5 [min] | 60.1 ± 10.9 | 155.7 ± 34.9 | 56.5 ± 16.9 | 55.2 ± 10.0 | 43.6 ± 5.4 | |
| R2 | 0.94 ± 0.03 | 0.92 ± 0.05 | 0.85 ± 0.03 | 0.94 ± 0.04 | 0.97 ± 0.01 | |
| S-O | k2 × 105 [mg−1 × min−1] | 3.8 ± 0.6 | 1.5 ± 0.2 | 4.2 ± 1.0 | 5.3 ± 0.5 | 5.8 ± 0.4 |
| t0.5 [min] | 55.1 ± 8.4 | 187.3 ± 39.1 | 110.1 ± 27.0 | 46.2 ± 6.2 | 35.1 ± 2.6 | |
| R2 | 0.95 ± 0.03 | 0.93 ± 0.05 | 0.89 ± 0.03 | 0.97 ± 0.02 | 0.99 ± 0.01 | |
| H | kH [mg × min−1/2] | 32.1 ± 3.4 | 17.3 ± 1.8 | 43.1 ± 3.6 | 5.4 ± 0.8 | 36.3 ± 4.4 |
| t0.5 [min] | 63.0 ± 13.4 | 258.4 ± 49.8 | 40.06 ± 6.6 | 2238.7 ± 673.6 | 47.0 ± 11.6 | |
| R2 | 0.97 ± 0.02 | 0.98 ± 0.01 | 0.98 ± 0.004 | 0.95 ± 0.02 | 0.97 ± 0.01 | |
| K–P | kK-P × 102 [min−n] | 1.8 ± 1.1 | 2.0 ± 0.2 | 5.6 ± 2.3 | 3.6 ± 1.2 | 1.4 ± 0.7 |
| t0.5 [min] | 33.0 ± 30.1 | 40.1 ± 25.7 | 20.3 ± 14.7 | 26.5 ± 17.0 | 30.2 ± 25.3 | |
| R2 | 0.92 ± 0.03 | 0.95 ± 0.02 | 0.90 ± 0.09 | 0.95 ± 0.03 | 0.92 ± 0.1 | |
| n | 0.95 ± 0.20 | 0.87 ± 0.1 | 0.74 ± 0.2 | 0.80 ± 0.1 | 0.99 ± 0.2 | |
| H–C | kH-C × 102 [mg1/3 × min−1] | 2.7 ± 0.5 | 1.3 ± 0.2 | 2.8 ± 0.9 | 2.9 ± 0.5 | 3.5 ± 0.5 |
| t0.5 [min] | 61.9 ± 12.3 | 147.7 ± 34.1 | 60.6 ± 19.6 | 58.6 ± 11.9 | 46.6 ± 7.1 | |
| R2 | 0.93 ± 0.03 | 0.91 ± 0.05 | 0.83 ± 0.04 | 0.93 ± 0.04 | 0.95 ± 0.02 | |
| best fit | H | H | H | S-O | S-O | |
Z-O—zero-order model; F-O—first-order model; S-O—second-order model; H—Higuchi model; K–P—Korsmeyer–Peppas model; H–C—Hixon–Crowell model.