Table 3.

The kinetic parameters of the second stage of the release of 5-ASA from F1–F5.

Kinetic Model	kinetic Parameters	F1	F2	F3	F4	F5
Z-O	k0 [mg × min−1]	0.12 ± 0.02	1.6 ± 0.02	0.08 ± 0.02	0.08 ± 0.01	0.06 ± 0.08
	t0.5 [min]	1262 ± 258	525 ± 94	3246 ± 784	2186 ± 366	3019 ± 488
	R2	0.86 ± 0.04	0.89 ± 0.05	0.82 ± 0.08	0.88 ± 0.05	0.91 ± 0.05
F-O	k1 × 104 [min−1]	6.3 ± 1.1	4.9 ± 0.8	4.0 ± 0.8	4.7 ± 0.7	3.9 ± 0.5
	t0.5 [min]	1168 ± 224	1431 ± 223	3077 ± 735	1562 ± 261	2070 ± 328
	R2	0.87 ± 0.04	0.90 ± 0.05	0.82 ± 0.09	0.89 ± 0.04	0.91 ± 0.05
S-O	k2 × 106 [mg−1 × min−1]	3.3 ± 0.6	1.8 ± 0.3	2.1 ± 0.4	3.4 ± 0.5	2.5 ± 0.3
	t0.5 [min]	1423 ± 263	1790 ± 275	4152 ± 986	1990 ± 319	2715 ± 426
	R2	0.88 ± 0.04	0.90 ± 0.05	0.82 ± 0.09	0.90 ± 0.03	0.92 ± 0.05
H	kH [mg × min−1/2]	3.9 ± 0.6	5.2 ± 0.8	2.4 ± 0.6	2.6 ± 0.4	1.9 ± 0.2
	t0.5 [min]	1422 ± 535	234 ± 83	15,552 ± 7072	4739 ± 1415	9304 ± 2776
	R2	0.89 ± 0.04	0.90 ± 0.06	0.80 ± 0.01	0.91 ± 0.03	0.92 ± 0.04
H–C	kH-C × 103 [mg1/3 × min−1]	1.2 ± 0.2	1.1 ± 0.2	0.8 ± 0.2	0.8 ± 0.1	0.7 ± 0.1
	t0.5 [min]	1090 ± 212	1337 ± 210	2720 ± 657	1352 ± 234	1928 ± 309
	R2	0.87 ± 0.04	0.90 ± 0.05	0.82 ± 0.07	0.89 ± 0.04	0.91 ± 0.05
best fit		H	F-O, S-O, H, H–C	Z-O, F-O, S-O, H–C	H	S-O, H

Z-O—zero-order model; F-O—first-order model; S-O—second-order model; H—Higuchi model; H–C—Hixon–Crowell model.