Figure 5.

KEGG pathways representation with the differentially expressed genes in CD4+CD28^null T lymphocytes with respect to CD4+CD28+ T lymphocytes stand out with colour. (A) Leucocyte transendothelial migration pathway (hsa 04670 entry). (B) Regulation of actin cytoskeleton pathway (hsa 04810 entry). Log₂ of the fold change extracted from migration array assays was calculated, and differentially expressed genes were represented in base of this value with a colour scale from dark red (upregulated genes in CD4+CD28^null T lymphocytes) to dark blue (downregulated genes in CD4+CD28^null T lymphocytes). Arrows mean activation. Dashed arrows mean indirect effect. Lines mean binding. Blunt end lines mean inhibition.