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. 2021 Jul 12;22(14):7455. doi: 10.3390/ijms22147455

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Relaxation of supercoiled DNA. (A) Relaxation of a negatively supercoiled plasmid DNA by htopIB at increasing concentrations of MMV024937 (lanes 2–10); lane 1: no drug added and lane 11: no protein added. (B) Relaxation of negative supercoiled plasmid DNA in a time course experiment with DMSO (lanes 1–9), 100 μM MMV024937 dissolved in DMSO (lanes 10–18), lane 19, no protein added. The reaction products are resolved on agarose gel and visualized with ethidium bromide. Dimer indicates dimer supercoiled plasmid DNA; SC indicates supercoiled plasmid DNA.