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. 2021 Jul 18;10(7):1816. doi: 10.3390/cells10071816

Figure 3.

Figure 3

IL-6 overexpression promotes muscle atrophy and wasting and affects the functional performance of skeletal muscle in adulthood. (a) Hematoxylin and eosin staining of transverse section of soleus muscles from indicated genotypes at 6 months of age. Scale bar 500 μm.(b–d) Analysis of morphologic and morphometric parameters in transgenic (NSE/IL-6) and wild type (WT) soleus muscle at 6 months of age. Data are represented as average ± SEM. n = 10; * p < 0.05, **** p < 0.0001. Statistical significance assessed by unpaired Student’s t-test. (e–g) Frequency distribution of myofiber-cross sectional area in transgenic (NSE/IL-6) and wild type (WT) soleus at 1.5 (e), 3.5 (f), and 6 (g) months of age. Data are represented as medians. n = 10; **** p < 0.0001. Statistical significance assessed by Mann–Whitney Rank Sum Test. (h–k) Physiological properties of soleus muscle from 3.5 (h,i) and 6 (j,k)-month-old wild type (WT) and NSE/IL-6 mice. Tetanic force and Specific force. Data are represented as average ± SEM. n = 15; * p < 0.05, **** p < 0.0001. Statistical significance assessed by unpaired Student’s t-test.