Table 1.
The IC50 and Hill slope values of α-CTx LvIF inhibit different nAChR subtypes.
| Subtype | IC50 (nM) a | Hill Slope a |
|---|---|---|
| rα3β2 | 8.98 (7.73–10.43) | 1.0 (0.9–1.2) |
| rα6/α3β2β3 | 14.43 (10.24–20.39) | 1.0 (0.7–1.1) |
| mα1β1δε | >10,000 b | |
| rα2β2 | >10,000 b | |
| rα2β4 | >10,000 b | |
| rα3β4 | >10,000 b | |
| rα4β4 | >10,000 b | |
| rα4β2 | >10,000 b | |
| rα6/α3β4 | >10,000 b | |
| rα7 | >10,000 b | |
| rα9α10 | >10,000 b |
a Values in parentheses are 95% confidence interval (C.I.). b Less than 50% blocking at 10 μM. All receptors are of rat (r) origin, except α1β1δε which is of mouse (m) origin.