Table 2.
Sequence comparison of α-CTx LvIF with α-CTxs that have similar activity for α3β2 nAChR.
| α-CTx | Organism | Sequence a | Target b | Ref. |
|---|---|---|---|---|
| LvIF | C. lividus | GCCSHPACAGNNQDIC# | rα3β2 > rα6/α3β2β3 | This work |
| RegIIA | C. regius | GCCSHPACNVNNPHIC# | rα3β2 > rα7 > rα6/rα3β2β3 > rα3β4 > rα6/α3β4 | [22] |
| MII | C. magus | GCCSNPVCHLEHSNLC# | rα6/α3β2β3 > rα3β2 > rα6/α3β4 | [23,24] |
| LvIA | C. lividus | GCCSHPACNVDHPEIC# | rα3β2 > rα6/α3β2β3 > rα6/α3β4 > rα3β4 | [11,25] |
| BuIA | C. bullatus | GCCSTPPCAVLY---C# | rα2β2 > rα2β4 > rα4β4 > rα3β2 > rα3β4 > rα6/α3β4 > rα6/α3β2β3 | [26] |
| PeIA | C. pergrandis | GCCSHPACSVNHPELC# | rα9α10 > rα6/α3β2β3 > rα3β2 > rα6/α3β4 > rα3β4 | [27] |
| GIC | C. geographus | GCCSHPACAGNNQHIC# | rα6/α3β2β3 ≥ rα3β2 > rα4β2 > rα3β4 | This work |
| hα6/α3β2β3 ≈ hα3β2 > hα4β2 > hα3β4 | [28,29,30] |
a The Cys residues that participate in the Framework I scaffold are in boxed. Conserved positions are on a light gray background. # Represents C-terminal carboxamide b r represents Rat and h represents human.