Table 2.

Univariate analysis of the lipid classifier panel. Six candidates were selected, with four decreasing and two increasing in SARS-CoV-2. Univariate statistics for the 275 lipids that were significant in the OPLS-DA (Figure 2) can be found in Table S5.

Discovery (Australia)
Lipid	Healthy Control Mean (sd)	SARS-CoV-2 Pos Mean (sd)	Mann–Whitney p	BH q Value	Cliff’s Delta	Cliff’s Delta 95%CI—Lower	Cliff’s Delta 95%CI—Upper
PE(P-18:1/18:2)	5.91 (2.09)	1.54 (0.84)	6.61 × 10−15	3.97 × 10−14	0.99	0.97	1.00
PC(18:2/18:2)	131.92 (46.05)	35.19 (22.5)	6.16 × 10−13	1.23 × 10−12	0.96	0.87	0.99
LPC(18:2)	37.31 (12.8)	13.9 (5.51)	3.22 × 10−13	9.66 × 10−13	0.97	0.89	0.99
HCER(22:0)	3.94 (0.89)	2.23 (0.51)	3.03 × 10−11	4.54 × 10−11	0.92	0.77	0.98
CER(18:0)	0.14 (0.05)	0.38 (0.17)	8.77 × 10−11	1.05 × 10−10	−0.91	−0.97	−0.72
DCER(18:0)	0.10 (0.04)	0.27 (0.12)	1.94 × 10−8	1.94 × 10−8	−0.82	−0.94	−0.56
Validation (Spain)
Lipid	Healthy Control Mean (sd)	SARS-CoV-2 Pos Mean (sd)	Mann–Whitney p	BH q Value	Cliff’s Delta	Cliff’s Delta 95%CI—Lower	Cliff’s Delta 95%CI—Upper
PE(P-18:1/18:2)	5.4 (1.99)	1.41 (1.26)	1.74 × 10−43	5.22 × 10−43	0.92	0.88	0.95
PC(18:2/18:2)	451.11 (156.5)	110.91 (100.96)	8.21 × 10−45	4.93 × 10−44	0.93	0.9	0.96
LPC(18:2)	51.23 (17.35)	17.19 (11.06)	6.38 × 10−43	1.28 × 10−42	0.91	0.86	0.94
HCER(22:0)	3.51 (0.96)	1.84 (0.92)	3.70 × 10−35	5.55 × 10−35	0.82	0.76	0.87
CER(18:0)	0.15 (0.05)	0.31 (0.18)	1.17 × 10−22	1.40 × 10−22	−0.65	−0.73	−0.56
DCER(18:0)	0.09 (0.04)	0.14 (0.09)	6.93 × 10−9	6.93 × 10−9	−0.38	−0.48	−0.28