Table 1.

Clinico-pathological characteristics.

Characteristics	Diagnoses
	HPV-Independent VSCC (n = 15)	HPV-Associated VSCC (n = 3)	Normal Vulvar Tissue (n = 6)
Median Age (Range) in years	76 (52–90)	73 (65–81)	75 (52–90)
Location
Vulvar skin with adnexa	8 (53)	1 (33)	1 (17)
Vulvar skin without adnexa	7 (47)	2 (67)	5 (83)
Treatment
Excision with lymph node dissection/sentinel node procedure	14 (94)	3 (100)	0 (0)
Excision only	1 (6)	0 (0)	6 (100)
Follow-up
No evidence of VIN/VSCC	7 (47)	2 (67)	6 (100)
VIN	1 (6)	0 (0)	0 (0)
VSCC recurrence	6 (41)	1 (33)	0 (0)
Died	1 (6)	0 (0)	0 (0)
p16-expression
Block-type	0 (0)	3 (100)	0 (0)
Non-block-type	8 (53)	0 (0)	1 (17)
No expression	7 (47)	0 (0)	5 (83)
p53-expression
Diffuse overexpression	9 (60)	1 (33)	0 (0)
Basal overexpression	1 (7)	0 (0)	0 (0)
Null pattern	3 (20)	0 (0)	0 (0)
Wild-type expression (scattered)	2 (13)	0 (0)	6 (100)
Wild-type expression (mid-epithelial)	0 (0)	2 (67)	0 (0)