Table 2.
Description of the five submaps of the CFTR high-throughput model.
| Process | Localization | Functional Category | N 1 |
|---|---|---|---|
| Transcription | Nucleus | DNA Replication | 7 |
| Transcription | 10 | ||
| RNA Processing | Nucleus–Cytoplasm | 36 | |
| Translation, Folding and ER quality control | ER | Folding | 57 |
| ER-associated degradation | 1 | ||
| both | 3 | ||
| unspecified | 653 | ||
| Secretory pathway | ER, Golgi apparatus, Plasma Membrane | 22 | |
| Activity and Regulation | Plasma Membrane | Activity | 38 |
| unspecified | 145 | ||
| Endocytosis, Recycling and Degradation | Plasma Membrane, Endosomes, Lysosomes | Recycling | 12 |
| Degradation | 32 | ||
| Cytoskeleton | Cytoplasm, Plasma Membrane | 62 | |
| Immunity | 10 | ||
| Other/Unknown | 250 |
1 Number of interactors present in the respective submap.