Figure A2.

Overview of network derived from IPA Core analysis, representing interactions between miRNAs found to be chemopredictive for carboplatin and genes relevant to the significant functions and diseases listed in Table 3 and Table 4. (A) miRNAs and their mRNA target genes. (B) Involvement of miRNAs in pathways, functions, and diseases. Canonical pathways (CP:) and functions and diseases (Fx:) as defined by IPA are overlaid to highlight the interconnectedness of the set with molecular processes relevant to chemoresponse. Predictive miRNAs whose expression was positively associated with survival are shown in green, and those whose expression was negatively associated are shown in red.