Table 4.
Total number of chemoresistant miRNAs when considering administration of specific chemotherapeutic agents in combination with variable administration of surgery and radiation, as evidenced by shortened disease-specific survival. The miRNAs which produced a significant stratification in the SEER population samples in addition to significance on one or more measures in the NCI-60, MRRCC, CWRU, TCGA, and CCLE are in bold.
| Treatment | Cisplatin | Carboplatin | Paclitaxel | Etoposide | Any Chemotherapy |
|---|---|---|---|---|---|
| Surgery |
miR-126*, miR-136, miR-181b, miR-181c, miR-196a (miR-196a-2), miR-331, miR-375, miR-424, miR-92 (miR-92a-1, miR-92b) |
miR-126, miR-192, miR-195, miR-384 |
miR-189, miR-192, miR-197, miR-301, miR-328, miR-331, miR-384 |
- | miR-197, miR-384 |
| Radiation | miR-384 | - | miR-189 | miR-150, miR-155, miR-192, miR-337, miR-98 |
miR-328 |
| Surgery and Radiation |
- | miR-192, miR-384 | miR-192, miR-197, miR-328, miR-331, miR-384 |
miR-223 | miR-328, miR-197, miR-384 |
| Any treatment |
miR-132, miR-181b, miR-30c, miR-30e-3p, miR-324-3p, miR-331, miR-339, miR-384 |
miR-126, miR-195, miR-224, miR-384 |
miR-126, miR-224, miR-328, miR-331, miR-361, miR-384 |
miR-132, miR-133b, miR-155, miR-197, miR-208, miR-214, miR-324-3p, miR-374, miR-423 |
miR-328, miR-361, miR-511, miR-197, miR-125a, miR-384, miR-126 |