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. 2021 Jul 15;22(14):7568. doi: 10.3390/ijms22147568

Figure 8.

Figure 8

Electrophoregrams in 1% agarose gel of supercoiled (sc) plasmid DNA digested with topoisomerase I (topo1), without or in the presence of the indicated substances: 1—DNA + topo1 (enzyme control); 2—1% DMSO (solvent control), 3—100 µM camptothecin (positive control); 4—134 10 µM; 5—138 10 µM, 6—TCAP 10 µM; 7—TCAP 20 µM; 8—100 µM camptothecin (positive control); 9—scDNA; 10—relaxed DNA (topoisomers); 11—linear DNA. Image A shows the electrophoregram of an ethidium bromide-stained gel after electrophoresis, and image B shows the result of DNA separation in a gel with ethidium bromide.