. 2021 Jul 8;22(14):7352. doi: 10.3390/ijms22147352

Table 1.

Molecular effects of miR-24 parathyroid glands and endocrine pancreas, and possible roles in MEN1 tumorigenesis.

miR-24 Target	Effect	Possible Role in MEN1 Tumorigenesis	Reference
	Parathyroid glands
MEN1	No effect on MEN1 mRNA expression. Loss of menin protein expression.	Uncontrolled cell proliferation	[27]
	Endocrine pancreas
MEN1	Reduction of both MEN1 mRNA and menin expression.	Uncontrolled cell proliferation	[36]
CDKN1B	Reduction of expression of both CDKN1B mRNA and of p27^kip1 protein in a mouse insulinoma cell line (MIN6).	Enhanced proliferation of beta-cells and hyperplasia of pancreas islets	[36]
CDKN1B	Reduction of expression of CDKN1B mRNA in an immortalized human pancreas beta cell line (Blox5). No data on expression of p27^kip1 protein.	Enhanced proliferation of beta-cells and hyperplasia of pancreas islets	[36]
CDKN2C	No effect on expression of both CDKN2C mRNA and of p18^Ink4c protein in a mouse insulinoma cell line (MIN6).	Non applicable	[36]
CDKN2C	Reduction of expression of CDKN2C mRNA in an immortalized human pancreas beta cell line (Blox5). No data on expression of p18^Ink4c protein.	Enhanced proliferation of beta-cells and hyperplasia of pancreas islets	[36]