Table 3.
Summary of the cited circRNAs involved in metabolic diseases and their mechanisms of action.
| Name | Functions | Targets |
|---|---|---|
| circRNA_1897 | ↑Adipocytes differentiation and lipid metabolism [192] | miR-27a and miR-27b-3p [192] |
| circRNA_26852 | Lipolysis and inhibition of adipocyte differentiation via a PPARγ-dependent mechanism [192] | miR-874 and miR-486 [192] |
| circ_0046367 | Activation of genes involved in lipid metabolism such as Cpt2 and Acbd3 [193] | miR-34a/PPARα [193] |
| circHIPK3 | ↑Lipid droplets accumulation following oleate treatment [194] | miR-192-5p/Foxo1 [194] |
| circ_0001946(circCDR1) | ↑Adipogenic differentiation ↓Osteogenic differentiation of BMSCs [195]; ↓Insulin secretion [197] | miR-7-5p/Wnt5 [195]; miR-7/Snca, Cspa, Cplx1 [197] |
| circRNA_0095570 (circH19) | ↓Lipids droplets formation and adipogenesis in ACDCs cells | Pparγ, Srebp1c and Cebp1- α |
| circ_Arhgap5-2 | ↓Adipogenesis markers [196] | Pparγ, Cebpα, Fabp4 and AdipoQ [196] |
| circRNA_0054633 | Biomarker of prediabetes in peripheral blood [198] | - |
| circ_ANKRD36 | Potential role in inflammatory mechanisms occurring in T2D [199] | - |
| circRNA_021412 | ↓long chain acyl-CoA synthetases and development of hepatic steatosis [200] | miR-1972/LPN1 [200] |
| circRNA_0046366 | ↑Hepatocyte steatosis [193] | miR-34a/PPARα [193] |
BMSCs: bone marrow stromal cells; ACDCs: adipose derived stem cells.