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The formation of the basic translation initiation complex in eukaryotes. The eukaryotic translation initiation factor (eIF) 4F complex (which consists of eIF4E, eIF4G, and eIF4A) is assembled on the 5′ cap of mRNAs with PABP. The 43S PIC consists of 40S, a small ribosomal subunit, and several eIFs, such as eIF3 and eIF2.
