Table 1.

Blue light in psoriasis vulgaris, atopic dermatitis, and eczema.

Skin Disease	Treatment Protocol	Irradiation Days Per Week	Irradiation Time (min)	Numer of Patients	Peak Wavelength (nm)	Intensity (mW/cm2)—Irradiance	Fluence (J/cm2)—Dose	Initial Seveity Index	Outcome	Reference	Year
Psoriasis vulgaris	3 times per week for 4 weeks	3	No information	17	417	8.5	10	LPSI around 6,6	No significant imporvement	[46]	2003
Psorisasis vulgaris	Every day (15 min) for 4 weeks	7	15	40	420 (group 1), 453 (group 2)	100	90	LPSI 5	Significant improvement in both groups	[39]	2011
Psoriais vulgaris	3 (20 min) times per week for 4 weeks	3	20	20	420	100	“high dose”	LPSI 7,7	33,9 % improvement,	[40]	2012
Psoriasis vulgaris	Every day (30 min) for 4 weeks and 3 times per week for the next 8 weeks	7 for 4 weeks and 3 for 8 weeks	30	47	453	100 and 200	90	LPSI 5,17 (200 mW/cm2 group) LPASI 5,52 (100 mW/cm2 group)	improvement of LPSI in both groups. 29.2% achieved reduction of LPSI between ≥25 and <50%, 33.3% between ≥50 and <75%, and 16.7% of more than 75%	[47]	2015
Psoriasis vulgaris	15 min or 30 min daily for 12 weeks	7	15 or 30	51	453	600	38 and 76	LPSI 5,31 (group 1), LPSI 4,8 (group 2)	improvement of about 50% in both groups	[48]	2019
Atopic dermatitis/hand and foot eczema	30 min 3 times per week for 4 weeks	3	30	10	40% between 400–500, 26% between 400–450	23	42	DASI (dyshidrosis area and severity index) 33,85	Significant improvement (DASI 23,3)	[50]	2005
Atopic dermatitis	1 cycle = 5 consecutive irradiations. 2–5 cycles for maximum 24 weeks	5	24 min of each side of the body	36	66% between 400–500 nm	No information	28,9	EASI 20,6 (6,8–54)	Improvement of about 54%	[51]	2011
Eczema	3 times per week for 4 weeks	3	No information	21	453	No information	90J	Local ESI (local Eczema Severity Index) 4	significant improvement of Local ESI (1,9)	[52]	2016