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. 2021 Jul 8;13(14):3427. doi: 10.3390/cancers13143427

Figure 4.

Figure 4

The modulatory effect of curcumin on the NF-κB pathway. Curcumin inhibits the NF-κB signaling pathway through the regulation of its key components. Curcumin upregulates IκB and miR181b expression and downregulates NF-κB and IKK, and suppresses the NF-κB translocation into the nucleus, which results in the inhibition of cellular proliferation, survival, metastasis, and angiogenesis in hormone receptor negative breast cancer. Cur: curcumin, IκK: inhibitor of kappa B kinase, IκB: inhibitor of NF-κB, Rel A: p65.