Table 5.
Patient, tumor, and treatment characteristics after propensity score matching and weighting.
| Variables | Propensity Score Matching | IPTW | |||||
|---|---|---|---|---|---|---|---|
| IMRT | PBSPT | SMD | IMRT | PBSPT | SMD | ||
| n = 50 | n = 25 | n = 197.0 | n = 53.6 | ||||
| Sex | Male | 42 (84.0) | 21 (84.0) | <0.001 | 153.7 (78.7) | 36.2 (67.5) | 0.238 |
| Age, years | 67.7 (7.0) | 67.5 (8.8) | 0.033 | 62.0 (9.0) | 60.1 (8.8) | 0.217 | |
| ECOG | 0–1 | 50 (100.0) | 23 (92.0) | 0.417 | 194 (98.5) | 52.5 (97.9) | 0.039 |
| Histology | ADC | 18 (36.0) | 9 (36.0) | <0.001 | 110.0 (56.4) | 35.3 (65.9) | 0.196 |
| EGFR mutant | 5 (10.00) | 2 (8.0) | 0.070 | 35.3 (17.9) | 14.9 (27.8) | 0.238 | |
| Clinical T stage | cT3–4 | 19 (38.0) | 10 (40.0) | 0.121 | 71.6 (36.4) | 33.8 (63.2) | 0.557 |
| Clinical N stage | cN3 | 26 (52.0) | 12 (48.0) | 0.080 | 138.7 (70.4) | 37.3 (69.6) | 0.017 |
| N3 region | Contralateral mediastinum | 13 (26.0) | 5 (20.0) | 0.143 | 82.4 (41.8) | 20.2 (37.7) | 0.084 |
| Supraclavicular | 14 (28.0) | 9 (36.0) | 0.172 | 68.7 (34.9) | 24.1 (45.0) | 0.207 | |
| Pre-treatment pulmonary function test | |||||||
| FEV1, % | 74.4 (20.0) | 73.1 (24.2) | 0.061 | 81.1 (18.7) | 78.6 (21.7) | 0.112 | |
| DLCO, % | 71.5 (22.0) | 67.0 (19.3) | 0.216 | 78.0 (19.2) | 82.3 (19.4) | 0.121 | |
| Radiation therapy | |||||||
| Gross tumor volume, cc | 191.8 (188.8) | 178.0 (151.2) | 0.080 | 156.9 (162.8) | 176.5 (133.6) | 0.131 | |
| Clinical target volume, cc | 443.4 (307.4) | 453.6 (307.3) | 0.033 | 378.9 (271.6) | 440.3 (260.8) | 0.231 | |
| Planning target volume, cc | 704.8 (405.3) | 734.4 (437.9) | 0.070 | 628.0 (361.1) | 711.7 (380.8) | 0.226 | |
Values are presented as number of patients (%) or mean (standard deviation). Abbreviations: IPTW, inverse probability of treatment weighting; IMRT, intensity-modulated radiation therapy; PBSPT, pencil beam scanning proton therapy; SMD, standardized mean difference; ADC, adenocarcinoma; EGFR, Epidermal growth factor receptor; FEV1, forced expiratory volume in 1 s; DLCO, diffusing capacity of the lung for carbon monoxide.