. 2021 Jul 16;10(14):3151. doi: 10.3390/jcm10143151

Table 1.

Demographic data, baseline scores, changes during treatment and correlations of patients who had tinnitus at baseline (data from three trials, absolute and relative frequency and p-value of the two-sided χ² test or mean ± standard deviation, p-value of the two-sided t-test and Pearson correlation coefficient, respectively).

					Baseline Scores				Change Scores
Trial ¹	Treatment	N	Female (%)	Age (Years)	Tinnitus	Depression	Anxiety	Cognition	Tinnitus	Depression	Anxiety	Cognition
A	EGb 761^®	102	76 (74.5%)	64.8 (8.5)	4.0 (1.6)	2.0 (1.6)	3.4 (2.6)	16.5 (3.5)	−2.1 (1.7)	−0.9 (1.4)	−1.3 (1.8)	−3.3 (2.2)
	Placebo	104	76 (73.1%)	63.7 (8.6)	3.9 (1.4)	2.1 (1.7)	3.8 (2.4)	16.0 (3.5)	−0.2 (1.0)	0.4 (1.5)	0.0 (1.9)	1.3 (2.1)
	p-value		0.815	0.378	0.527	0.550	0.2764	0.265	<0.001	<0.001	<0.001	<0.001
B	EGb 761^®	90	65 (72.2%)	65.0 (9.7)	2.9 (1.5)	1.5 (1.8)	2.2 (2.1)	16.6 (3.8)	−1.1 (1.2)	−0.7 (1.4)	−0.6 (1.6)	−1.9 (2.8)
	Placebo	107	73 (68.2%)	65.2 (9.2)	2.9 (1.5)	1.7 (1.9)	2.4 (2.2)	17.1 (3.5)	−0.1 (0.9)	−0.1 (1.3)	−0.0 (1.8)	0.4 (2.7)
	p-value		0.542	0.8907	0.977	0.473	0.501	0.336	<0.001	0.002	0.014	<0.001
C	EGb 761^®	97	68 (70.1%)	65.9 (8.6)	2.9 (1.6)	2.9 (2.4)	3.5 (2.3)	15.2 (3.9)	−0.8 (1.4)	−0.6 (2.0)	−1.1 (2.0)	−2.1 (3.0)
	Placebo	94	65 (69.1%)	66.7 (9.7)	3.0 (1.4)	2.9 (2.1)	3.4 (2.4)	16.1 (3.9)	−0.7 (1.2)	−0.4 (1.8)	−0.7 (1.6)	−0.3 (2.8)
	p-value		0.886	0.578	0.576	0.931	0.698	0.138	0.440	0.464	0.1853	<0.001
Overall	EGb 761^®	289	209 (72.3%)	65.2 (8.9)	3.3 (1.7)	2.1 (2.0)	3.1 (2.4)	16.1 (3.8)	−1.4 (1.6)	−0.7 (1.6)	−1.0 (1.8)	−2.5 (2.7)
	Placebo	305	214 (70.2%)	65.1 (9.2)	3.3 (1.5)	2.2 (2.0)	3.2 (2.4)	16.4 (3.7)	−0.3 (1.1)	−0.0 (1.5)	−0.2 (1.8)	0.5 (2.6)
	p-value		0.562	0.906	0.864	0.634	0.582	0.352	<0.001	<0.001	<0.001	<0.001
Influence of baseline depression/anxiety/cognition on tinnitus severity ²						p = 0.172	p = 0.006	p = 0.715
Correlation between tinnitus score change and depression/anxiety/cognition score change during treatment									EGb 761^®	0.234	0.202	0.187
									Placebo	0.241	0.204	0.339

¹ Subgroups of patients suffering from tinnitus in trials of Napryeyenko et al. [42] (A), Ihl et al. [43] (B) and Herrschaft et al. [44] (C). ² Multiple regression to investigate the influence of baseline depression, anxiety and cognition on tinnitus severity.