Table 3.

Estimation of indirect effects using the bootstrap method—model with three mediators based on pooled data from three trials (subset of patients with tinnitus at baseline, full analysis set); parameter estimate, standard error (SE) and 95% confidence interval (CI).

Effect	Estimate	SE	95% CI
a1 × b1 + a2 × b2 + a3 × b3: indirect effects (combined)	0.4380	0.077	(0.2899; 0.5952)
a1 × b1: indirect effect mediated by reduced depression	0.0877	0.032	(0.0319; 0.1590)
a2 × b2: indirect effect mediated by reduced anxiety	0.0830	0.032	(0.0282; 0.1523)
a3 × b3: indirect effect mediated by improved cognition	0.2672	0.074	(0.1241; 0.4186)