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. 2021 Jul 11;26(14):4212. doi: 10.3390/molecules26144212

Table 4.

Comparison of selected biological/pharmacological activities of oxyresveratrol and resveratrol.

Biological/Pharmacological Activity Oxyresveratrol Resveratrol Reference
(1) Antioxidant and anti-inflammatory activities
DPPH higher [61,94]
O2− • higher [61]
H2O2 higher [94,165]
NO higher [94]
FRAP higher [164]
ABTS+ • higher [61,116,164]
ORAC higher [164]
Inhibition of LPS-induced production of NO in BV-2 microglial cells higher [18,168]
COX-1, COX-2 higher [166]
5-Lipoxigenase higher [166]
Protection against CCl4--induced liver fibrosis in rats higher [204]
Inhibition of PAF-induced release of β-glucuronidase in rat polymorphonuclear leukocytes higher [117]
(2) Inhibition of tyrosinase or melanogensis
Mushroom tyrosinase (l-dopa) higher [124,138,148]
higher [152]
Mushroom tyrosinase (l-tyrosine) higher [61,138,151,152]
Murine tyrosinase (l-tyrosine) higher [149]
Cellular tyrosinase activity and melanogenesis in B16F0 cells higher [128,153]
Melanogenesis in Streptomyces bikiniensis higher [154]
(3) Neuroprotection
Prevention of 6-OHDA neurotoxicity
(Model of Parkinson’s disease)
higher [79,196,197]
Prevention of KA neurotoxicity higher [199]
Prevention of EtOH neurotoxicity higher [41]
(4) Glucose and lipid metabolism
Inhibition of α-glucosidase higher [220]
Stimulation of insulin secretion in MIN 6 cells higher [226]
Stimulation of glucokinase activity and expression higher [223]
Inhibition of AGE (advanced glycation end-products) formation
Model of BSA-acrolein higher [225]
Model of BSA-glucose higher [124]
Model of BSA-methylglyoxal higher [225]
Stimulation of PGC-1β-mediated gene expression (Peroxisome proliferator activated receptor gamma co-activator-1β) higher [230]
Reduction of Firmicutes to Bacteroidetes ratio (F/B) in feces higher [248]
(5) Antimicrobial activities
Antifungal activity higher [125]
Inhibition of Staphylococcus aureus (Gram positive) higher [244]
Inhibition of quorum-sensing of Chromobacterium violaceum (Gram negative) higher [247]
(6) Others
Inhibition of phosphodiesterase-2 higher [264]
Inhibition of phosphodiesterase-4 higher [257]