Table 4.
Comparison of selected biological/pharmacological activities of oxyresveratrol and resveratrol.
Biological/Pharmacological Activity | Oxyresveratrol | Resveratrol | Reference |
---|---|---|---|
(1) Antioxidant and anti-inflammatory activities | |||
DPPH | higher | [61,94] | |
O2− • | higher | [61] | |
H2O2 | higher | [94,165] | |
NO• | higher | [94] | |
FRAP | higher | [164] | |
ABTS+ • | higher | [61,116,164] | |
ORAC | higher | [164] | |
Inhibition of LPS-induced production of NO in BV-2 microglial cells | higher | [18,168] | |
COX-1, COX-2 | higher | [166] | |
5-Lipoxigenase | higher | [166] | |
Protection against CCl4--induced liver fibrosis in rats | higher | [204] | |
Inhibition of PAF-induced release of β-glucuronidase in rat polymorphonuclear leukocytes | higher | [117] | |
(2) Inhibition of tyrosinase or melanogensis | |||
Mushroom tyrosinase (l-dopa) | higher | [124,138,148] | |
higher | [152] | ||
Mushroom tyrosinase (l-tyrosine) | higher | [61,138,151,152] | |
Murine tyrosinase (l-tyrosine) | higher | [149] | |
Cellular tyrosinase activity and melanogenesis in B16F0 cells | higher | [128,153] | |
Melanogenesis in Streptomyces bikiniensis | higher | [154] | |
(3) Neuroprotection | |||
Prevention of 6-OHDA neurotoxicity (Model of Parkinson’s disease) |
higher | [79,196,197] | |
Prevention of KA neurotoxicity | higher | [199] | |
Prevention of EtOH neurotoxicity | higher | [41] | |
(4) Glucose and lipid metabolism | |||
Inhibition of α-glucosidase | higher | [220] | |
Stimulation of insulin secretion in MIN 6 cells | higher | [226] | |
Stimulation of glucokinase activity and expression | higher | [223] | |
Inhibition of AGE (advanced glycation end-products) formation | |||
Model of BSA-acrolein | higher | [225] | |
Model of BSA-glucose | higher | [124] | |
Model of BSA-methylglyoxal | higher | [225] | |
Stimulation of PGC-1β-mediated gene expression (Peroxisome proliferator activated receptor gamma co-activator-1β) | higher | [230] | |
Reduction of Firmicutes to Bacteroidetes ratio (F/B) in feces | higher | [248] | |
(5) Antimicrobial activities | |||
Antifungal activity | higher | [125] | |
Inhibition of Staphylococcus aureus (Gram positive) | higher | [244] | |
Inhibition of quorum-sensing of Chromobacterium violaceum (Gram negative) | higher | [247] | |
(6) Others | |||
Inhibition of phosphodiesterase-2 | higher | [264] | |
Inhibition of phosphodiesterase-4 | higher | [257] |