Table 4.
Univariate and multivariate analysis of the association with weight loss (≥7%) or nasogastric tube insertion.
| Characteristics | Univariate Analysis | MVA without Radiation Dose | MVA with Radiation Dose | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | p-Value | OR | 95% CI | p-Value | OR | 95% CI | p-Value | |
| Age | |||||||||
| <60 | 1 | 1 | 1 | ||||||
| ≥60 | 0.562 | 0.234–1.350 | 0.197 | 0.419 | 0.156–1.126 | 0.085 | 0.445 | 0.167–1.183 | 0.105 |
| Sex | |||||||||
| female | 1 | 1 | 1 | ||||||
| Male | 0.995 | 0.429–2.311 | 0.991 | 1.110 | 0.455–2.712 | 0.818 | 1.168 | 0.468–2.913 | 0.739 |
| Pathology | |||||||||
| WHO I, II | 1 | 1 | 1 | ||||||
| WHO III | 0.858 | 0.434–1.697 | 0.660 | 0.864 | 0.406–1.839 | 0.704 | 0.956 | 0.439–2.081 | 0.909 |
| T stage | |||||||||
| I–II | 1 | 1 | 1 | ||||||
| III–IV | 1.985 | 1.055–3.737 | 0.034 * | 2.195 | 1.072–4.493 | 0.031 * | 1.827 | 0.865–3.858 | 0.114 |
| N stage | |||||||||
| 0–I | 1 | 1 | 1 | ||||||
| II–III | 1.487 | 0.772–2.864 | 0.235 | 1.742 | 0.751–4.042 | 0.196 | 1.429 | 0.590–3.460 | 0.429 |
| Radiationmodality | |||||||||
| VMAT | 1 | 1 | 1 | ||||||
| IMPT | 0.358 | 0.188–0.680 | 0.002 * | 0.302 | 0.150–0.607 | 0.001 * | 0.828 | 0.238–2.888 | 0.768 |
| Mean oralcavity dose | 1.063 | 1.031–1.095 | 0.000 * | 1.069 | 1.003–1.140 | 0.038 * | |||
| Mean superior Constrictor muscle dose | 0.997 | 0.989–1.005 | 0.441 | 0.994 | 0.977–1.011 | 0.472 | |||
| Mean middle Constrictor muscle dose | 1.035 | 1.002–1.069 | 0.036 * | 0.984 | 0.946–1.023 | 0.407 | |||
| Mean inferior Constrictor muscle dose | 1.043 | 1.001–1.085 | 0.042 * | 1.010 | 0.980–1040 | 0.531 | |||
| EBV titer | |||||||||
| ≥200 | 1 | 1 | 1 | ||||||
| <200 | 1.729 | 0.906–3.298 | 0.097 | 1.024 | 0.438–2.394 | 0.957 | 1.186 | 0.481–2.922 | 0.711 |
| Chemotherapy modality | |||||||||
| No | 1 | 1 | 1 | ||||||
| Concurrent | 2.373 | 0.854–6.591 | 0.097 | 1.691 | 0.521–5.487 | 0.382 | 1.368 | 0.412–4.542 | 0.608 |
| Induction | 1.436 | 0.391–5.269 | 0.585 | 0.759 | 0.165–3.497 | 0.724 | 0.612 | 0.129–2.908 | 0.537 |
| Smoking | |||||||||
| No | 1 | 1 | 1 | ||||||
| Yes | 1.017 | 0.544–1.900 | 0.959 | 0.981 | 0.489–1.970 | 0.958 | 1.094 | 0.526–2.275 | 0.811 |
Abbreviations: MVA—Multivariate analysis, OR—Odds ratio, CI—Confidence interval, IMPT—Intensity-modulated proton therapy, VMAT—Volumetric modulated arc therapy, WHO—World Health Organization; * means statistically significant.