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. 2021 Jul 15;26(14):4295. doi: 10.3390/molecules26144295

Figure 9.

Figure 9

Ziziphus nummularia inhibits the ERK1/2 and NFκB signaling pathways in pancreatic cancer cells. (a) Ziziphus nummularia downregulates the level of phosphorylated ERK1/2. Cells were treated without or with ZNE (200 μg/mL) for 5 and 10 min, and protein lysates were examined for the level of phosphorylated ERK1/2. Data are representative of three independent experiments. (b) Ziziphus nummularia inhibits NF-κB transcriptional activity. Capan-2 cells were transfected with the pGL4.32[luc2P/NF-κB-RE/Hygro] expression plasmid, and luciferase activity was measured 18 h post-transfection as described in Materials and Methods. Data represent the means ± SEM of three independent experiments. * denotes p < 0.05.