Figure 2.

Xenograft mice model of acrolein-transformed clones. (A) Overall view of tumors formed by acrolein-transformed NOK cell clone (NOK Acr-clone #4). Tumors in nude mice were seen after injection with acrolein-transformed clone #4, whereas none were seen after orthotopic injection with normal human oral keratinocytes (NOK). (B) Tumor growth curves and (C) body weight for nude mice of different experimental groups (n = 5). Student’s t-tests were used to determine statistical significance, and two-tailed p-values are shown. *** p < 0.005 compared with NOK parental cells.