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. 2021 Jul 6;11(7):639. doi: 10.3390/jpm11070639

Table 4.

Comparison of patients with nutrition-related risk present and no nutrition-related risk based on GNRI formula.

Characteristics No Nutrition-Related Risk (GNRI > 98) Nutrition-Related Risk Present (GNRI ≤ 98) p
(n = 88) (n = 9)
age (years) 53.9 ± 10.9 57.3 ± 8.0 0.44
men 71 (80.7%) 6 (66.7%) 0.58
BMI (kg/m2) 28.9 ± 5.5 22.8 ± 2.6 0.0001
IHD etiology 41 (46.6%) 4 (44.4%) 0.82
HF exacerbation 31 (35.2%) 2 (22.2%) 0.64
SBP on admission (mmHg) 113.2 ± 23.7 98.3 ± 10.0 0.03
DBP on admission (mmHg) 74.7 ± 12.9 66.8 ± 7.2 0.07
HR on discharge (beats per minute) 73.6 ± 13.1 75.6 ± 14.7 0.64
Comorbidities
DM 26 (29.5%) 1 (11.1%) 0.43
COPD 8 (9.1%) 0 0.76
CKD 14 (15.9%) 1 (11.1%) 0.93
hypertension 46 (52.3%) 5 (55.6%) 0.87
NYHA class 0.84
I 3 (3.4%) 0 0.57
II 39 (44.3%) 3 (33.3%) 0.70
III 39 (44.3%) 5 (55.6%) 0.52
IV 7 (8.0%) 1 (11.1%) 0.74
I–II 42 (47.7%) 3 (33.3%) 0.64
III–IV 46 (52.3%) 6 (66.7%)
Biochemical parameters
Na+ (mmol/L) 138.9 ± 3.7 139.2 ± 2.5 0.97
BNP level (pg/mL) 685 ± 728 1038 ± 853 0.18
uric acid (µmol/L) 460.1 ± 136.1 462.1 ± 139.1 0.90
creatinine (µmol/L) 101.4 ± 29.5 105.4 ± 38.9 0.93
eGFR 73.8 ± 23.6 67.0 ± 18.7 0.64
K+ (mmol/L) 4.29 ± 0.39 4.04 ± 0.35 0.07
hsCRP (mg/L) 7.0 ± 9.3 5.7 ± 4.3 0.74
fasting glucose (mmol/l) 6.44 ± 2.07 5.62 ± 1.20 0.20
serum protein (g/L) 71.8 ± 7.2 66.1 ± 9.3 0.08
serum albumin (g/L) 41.1 ± 4.5 33.3 ± 5.4 <0.00001
TBIL (µmol/L) 19.3 ± 10.4 23.0 ± 17.3 0.62
ALT (U/L) 39.0 ± 22.4 32.2 ± 14.2 0.49
GGTP (U/L) 117.0 ± 122.6 95.0 ± 83.8 0.91
CholT (mmol/L) 4.33 ± 1.16 4.56 ± 0.70 0.40
TG (mmol/L) 1.55 ± 0.81 1.46 ± 0.66 0.87
LDL (mmol/L) 2.60 ± 0.92 2.70 ± 0.67 0.58
HDL (mmol/L) 1.21 ± 0.32 1.19 ± 0.34 0.75
Hb [mmol/L] 9.0 ± 1.0 8.4 ± 1.6 0.38
Nutritional parameters
CNAQ score 28.6 ± 3.9 27.9 ± 2.9 0.47
impaired appetite CNAQ ≤ 28 41 (47%) 4 (44.4%) 0.81
MNA score 23.5 ± 2.4 21.4 ± 3.1 0.046
malnourished (MNA score < 17) 0 0
at risk of malnutrition (MNA score 17–23.5) 44 (50%) 3 (33.3%) 0.34
normal nutritional status (MNA score > 23.5) 44 (50%) 6 (66.6%) 0.34
GNRI 115.1 ± 10.7 92.2 ± 4.4 <0.00001
Medications
loop diuretics 82 (93.2%) 9 (100%) 0.96
thiazides 15 (17.0%) 2 (22.2%) 0.93
ß-blocker 85 (96.6%) 8 (88.9%) 0.66
ACEI/ARB 67 (76.1%) 6 (66.7%) 0.78
ARNI 14 (15.9%) 1 (11.1%) 0.94
MRA 77 (87.5%) 9 (100%) 0.62
Ca-blocker 6 (6.8%) 0 0.93
statin 54 (61.4%) 5 (55.6%) 0.98
Echocardiographic parameters
LVEF (%) 23.4 ± 7.8 23.8 ± 7.6 0.83
LVEDD (mm) 71.3 ± 11.0 61.2 ± 11.5 0.02
RVD (mm) 37.8 ± 8.5 37.8 ± 7.6 0.96
LAD (mm) 52.9 ± 10.6 48.0 ± 8.6 0.21
IVS (mm) 10.0 ± 1.7 11.4 ± 3.4 0.37
PWD (mm) 9.9 ± 1.3 11.2 ± 4.5 0.84
Ao (mm) 33.5 ± 5.0 32.6 ± 4.1 0.49

BMI—body mass index, IHD—ischemic heart disease, SBP—systolic blood pressure, DBP—diastolic blood pressure, HR—heart rate, DM—diabetes mellitus, COPD—chronic obstructive pulmonary disease, CKD—chronic kidney disease, NYHA—New York Heart Association Classification, Na+ sodium concentration, BNP—B-type natriuretic peptide, NT-proBNP—N-terminal pro B-type natriuretic peptide, eGFR–estimated glomerular filtration rate, K+—potassium concentration, hsCRP-high-sensitivity C-reactive protein, TBIL—total bilirubin, ALT—alanine transaminase, GGTP—gamma-glutamyltranspeptidase, CholT—total cholesterol, TG—triglycerides, LDL—low density lipoprotein, HDL—high density lipoprotein, Hb—hemoglobin, CNAQ—The Council on Nutrition Appetite Questionnaire, MNA—The Mini Nutritional Assessment, GNRI—Geriatric Nutritional Risk Index, ACEI—angiotensin converting enzyme inhibitor, ARB—angiotensin receptor blocker, ARNI—angiotensin receptor-neprilysin inhibitor, MRA—mineralocorticoid receptor antagonist, LVEF—left ventricular ejection fraction, LVEDD—left ventricular end-diastolic diameter, RVD—right ventricular diameter, LAD—left atrium diameter, IVS—interventricular septum thickness, PWD—posterior wall of left ventricle, Ao—aorta.