Table 4.
Patents/patent applications for antioxidant, anti-inflammatory and antitumor products containing phlorotannin extracts (PhExt) or compounds.
| Product | Seaweed Species | Claims | Active Ingredients | Patent/Patent Application nr |
|---|---|---|---|---|
| PhExt with antioxidant activity | E. cava | Method for production of a phlorotannin extract with high antioxidant activity for cosmetic application using supercritical extraction | E. cava extract with 10%–15% phlorotannins | KR20080004758A [137] |
| PhExt with antioxidant activity | Bifurcaria bifurcata + A. nodosum | Method for production of a phlorotannin extract with antioxidant activity for cosmetic and food application using ultrasound assisted extraction | B. bifurcate extract containing 62.4 mg eq. of phloroglucinol/g and A. nodosum extract containing 44 mg eq. of phloroglucinol/g. | US2016074317A1 [138] |
| Antioxidant composition | E. stolonifera | Production of a composition of several phlorotannins isolated from E. stolonifera with high antioxidant activity for application in functional foods to prevent oxidative spoilage or pharmaceuticals for preventing aging | Eckstolonol, eckstolonol pentaacetate, eckol, phlorofucofuroeckol A and dieckol | KR20040095125A [139] |
| Antioxidant composition | I. okamurae | Production of an antioxidant composition containing phlorotannins isolated from I. okamurae for application in pharmaceuticals, food supplements and cosmetics aiming the prevention of ROS-related diseases | Phloroglucinol, 6,6’-bieckol or diphlorethohydroxycarmalol | KR20100039104A [140] |
| PhExt and anti-inflammatory composition | F. vesiculosus + A. nodosum | Method for production extracts with high content of phlorotannins and further production of an anti-inflammatory composition using these phlorotannin-rich extracts as active ingredient for application in medicaments for treating allergies and arthritis | Algal extract containing 11%–19% phlorotannins | FR2914190A1 [142] |
| Anti-inflammatory composition | E. stolonifera and E. cava | Production of a composition containing E. stolonifera and E. cava phlorotannin extracts or isolated phlorotannins for application in farmaceutical formulations aiming the inhibition of iNOS and COX-2 on inflammatory-related diseases | Phlorofucofuroeckol A | KR20120054577A [141] |
| Anti-MMP composition | Brown seaweeds | Production of a composition containing phlorotannins from brown seaweeds with inhibitory effects against matrix metalloproteinases to be used in form of powders, tablets, capsules, ointment compositions, solutions, gels, pastes, patches, granules for the treatment of wound, cancer metastasis, rheumatoid arthritis, inflammation, hyperparathyroidism, diabetes, corneal ulcer, osteoporosis, stomach ulcer, acne, burn, periodontal diseases, arteriosclerosis and fracture | Dieckol and bieckol | KR20080005711A [143] |
| Anti-cancer composition | E. cava | Production of a composition containing eckol isolated from E. cava capable of suppressing tumorigenesis, cancer growth, invasion, metastasis and malignance in k-Ras expressing cancers via inhibition of the PI3K-Akt signaling and Ras signaling through Ras-Raf-ERK signal transduction system | Eckol | KR20130104543A [145] |
| Anti-cancer composition | E. cava | Production of a composition containing eckol isolated from E. cava for prevention of cancer stem cell growth via suppression of the Ras signaling through the Ras-Raf-ERK signal transduction system | Eckol | KR20120053265A [145] |
MMP—matrix metalloproteinase; PhExt—phlorotannin extrac.