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. 2021 Jul 15;118(29):e2026813118. doi: 10.1073/pnas.2026813118

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Copyright © 2021 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 1. — LncRNA RMRP is overexpressed in colorectal cancer and associated with unfavorable prognosis. (A) RMRP expression is higher in colon cancer (n = 79) compared with normal tissues (n = 14). (B) RMRP expression is higher in colon cancer tissues (n = 14) compared with the paired adjacent tissues (n = 14). Values are expressed as the median with interquartile range in A and B. (C) A higher level of RMRP predicts poorer prognosis in 79 colon cancer patients. (D) RMRP expression is higher in cancerous tissues compared with the adjacent normal tissues through a colorectal cancer tissue array determined by RNA in situ hybridization. (E) Statistical analysis of RMRP staining in the colorectal cancer tissues (n = 93) and the adjacent tissues (n = 87). Statistical significance was assessed using Fisher’ s exact test. (F) Higher level of RMRP is associated with worse overall survival in 93 colorectal cancer patients. (G) Higher expression of RMRP is associated with worse overall survival in the TCGA rectum adenocarcinoma cohort.