Table 3.
Unadjusted and adjusted associations of viruses and microbiome profiles with hospitalization.
| Pathogen | Unadjusted OR | 95% CI | sig | Adjusted OR | 95% CI | sig | |
|---|---|---|---|---|---|---|---|
| Adenovirus | 0.46 | 0.182–1.161 | 0.1 | 0.388 | 0.137–1.095 | 0.074 | |
| Bocavirus | 2.69 | 0.561–12.907 | 0.216 | ||||
| Enterovirus | 0.076 | 0.016–0.353 | 0.001 | 0.078 | 0.015–0.395 | 0.002 | |
| Coronavirus | 1.37 | 0.340–5.519 | 0.685 | ||||
| Rhinovirus | 1.087 | 0.559–2.114 | 0.805 | ||||
| hMPV | 1.055 | 0.395–2.818 | 0.915 | ||||
| Influenza A | 0.842 | 0.136–5.193 | 0.853 | ||||
| Parainfluenza | 0.532 | 0.177–1.602 | 0.262 | ||||
| RSV | 1.368 | 0.631–2.968 | 0.427 | ||||
| Virusgroups | |||||||
| High virulence | 1.167 | 0.411–3.315 | 0.772 | ||||
| Low virulence | 0.899 | 0.310–2.607 | 0.845 | ||||
| Negative | ref | ||||||
| PCR positive for virus | 1.038 | 0.384–2.807 | 0.941 | ||||
| Microbiome profiles | |||||||
| Haemophilus | ref | ref | |||||
| Moraxella | 1.129 | 0.287–4.441 | 0.862 | 1.303 | 0.268–6.343 | 0.743 | |
| Streptococcus | 2.118 | 0.210–21.389 | 0.525 | 2.877 | 0.220–37.641 | 0.420 | |
Data are presented as odds ratios with 95% confidence intervals and p-value as calculated by logistic regression. In the multivariate models, odds ratios were adjusted for age, gender, detection, and virus in the nasopharyngeal sample and Feverkidstool risk groups. Definition of abbreviations: OR = odds ratio, CI = confidence interval, hMPV = human metapneumovirus RSV = respiratory syncytial virus.