Figure 6.

Sample representative histological analysis with hematoxylin–eosin (H.E.) reaction on tibialis anterioris (TA) muscles of (A) WT, (B,D,E) SUR2^AV/AV and (C) SUR2^wt/AV mice. (B) TA muscle from SUR2^AV/AV mice showed heterogenous population of myofibers with reduced area (arrows) (10×, Bar 50 μm), (D) no longer polygonal in shape but elongated, rounded and angular, with hyper-eosinophil sarcoplasm (arrow) (H.E. 40×, Bar 50 μm). (E) Hyperchromatic nuclei can be grouped together, and present fragmented myo-fibers separated by an accumulation of pale pink interstitial material of inflammatory origin in TA muscle from SUR2^AV/AV mice (H.E. 40×, Bar 50 μm).