Study design for blood cell trait focused TWAS analyses in African ancestry (AA) and Hispanic/Latino (HL) populations. TWAS: Transcriptome-wide association study; DGN: Depression Genes and Networks, n = 922; MESA: Multi-Ethnic Study of Atherosclerosis, n = 229 for AA and n = 381 for HL; ARIC: Atherosclerosis Risk in Communities, n = 2874; BioMe: BioMeTM Biobank, n = 3550 for AA and n = 4730 for HL; CARDIA: Coronary Artery Risk Development in Young Adults, n = 953; GERA: Genetic Epidemiology Research on Adult Health and Aging, n = 3699 for AA and n = 7348 for HL; UKB: UK Biobank, n = 8262; WHI: Women’s Health Initiative, n = 8617 for AA and n = 4359 for HL; HCHS/SOL: Hispanic Community Health Study/Study of Latinos, n = 11,887.