Table 1.

The table shows the marginally significant results discovered by MESA HL for all four phenotypes. “NA” denotes there is no known variants +/− 1 MB around the gene.

Gene	Chr	Start_hg38	End_hg38	Phenotype	Meta_beta	Meta_se	Direction	Marginal p-Value	Conditional p-Value	Model R2	Cross-Validation R2	TWAS Reference Panel	Discovery Population
ADAM15	1	155050566	155062775	HCT	−0.078	0.018	(−−−−+)	8.74 $\times {10}^{-6}$	2.52 $\times {10}^{-1}$	0.301	0.395	MESA	HL
THBS3	1	155195588	155209051	HCT	0.212	0.039	(+++++)	5.40 $\times {10}^{-8}$	9.22 $\times {10}^{-1}$	0.1	0.060	MESA	HL
GTF2IRD2B	7	75092573	75149817	HCT	−0.249	0.056	(−−−−−)	9.18 $\times {10}^{-6}$	NA	0.138	0.004	MESA	HL
AGAP6	10	49982190	50010499	HCT	−0.231	0.059	(−−−−−)	8.44 $\times {10}^{-5}$	NA	0.119	0.017	MESA	HL
SMAD6	15	66702228	66782849	HCT	−0.356	0.081	(−−−−+)	1.14 $\times {10}^{-5}$	8.55 $\times {10}^{-6}$	0.074	0.005	MESA	HL
ADAM15	1	155050566	155062775	HGB	−0.066	0.018	(−−−−+)	3.95 $\times {10}^{-5}$	1.51 $\times {10}^{-1}$	0.301	0.395	MESA	HL
THBS3	1	155195588	155209051	HGB	0.159	0.039	(++++-)	2.88 $\times {10}^{-5}$	7.71 $\times {10}^{-1}$	0.1	0.060	MESA	HL
ARHGAP19	10	97222173	97292673	HGB	−0.215	0.056	(−−−−+)	7.15 $\times {10}^{-5}$	NA	0.1	0.011	MESA	HL
CCDC15	11	124954121	125041489	HGB	0.059	0.016	(++++−)	5.84 $\times {10}^{-5}$	NA	0.342	0.235	MESA	HL
SMAD6	15	66702228	6678284	HGB	−0.344	0.080	(−−−−+)	9.0 $\times {10}^{-6}$	4.77 $\times {10}^{-5}$	0.074	0.005	MESA	HL
IL6R	1	154405193	154469450	PLT	−0.232	0.058	(−−−−+)	6.06 $\times {10}^{-5}$	7.63 $\times {10}^{-1}$	0.065	0.014	MESA	HL
BAK1	6	33572547	33580293	PLT	−0.118	0.029	(−−−+−)	4.95 $\times {10}^{-5}$	2.42 $\times {10}^{-1}$	0.167	0.088	MESA	HL
PAQR8	6	52361421	52407777	PLT	0.080	0.019	(+++++)	4.79 $\times {10}^{-5}$	1.27 $\times {10}^{-3}$	0.268	0.165	MESA	HL
TNFAIP2	14	103123442	103137439	PLT	−0.265	0.065	(−−−−−)	6.85 $\times {10}^{-5}$	8.10 $\times {10}^{-3}$	0.095	0.013	MESA	HL
SLC22A4	5	132294394	132344190	WBC	0.117	0.027	(+++++)	1.73 $\times {10}^{-5}$	1.53 $\times {10}^{-1}$	0.172	0.126	MESA	HL
BAK1	6	33572547	33580293	WBC	−0.110	0.028	(−−−−+)	9.47 $\times {10}^{-5}$	1.46 $\times {10}^{-4}$	0.167	0.088	MESA	HL
GRINA	8	143990056	143993415	WBC	−0.298	0.077	(−−+−−)	9.70 $\times {10}^{-5}$	NA	0.066	0.004	MESA	HL
ATXN2	12	111443485	111599676	WBC	−0.338	0.071	(−−+−+)	1.56 $\times {10}^{-6}$	2.12 $\times {10}^{-3}$	0.079	0.003	MESA	HL