Table 2.
Hazard Ratios of BMI at Diagnosis and Mortality Rates.
| Characteristic | Patient (n = 41015) |
Event (n = 15021) |
Age-, Gender-Adjusted HR | p-Value | Age-, Gender-,Stage- Adjusted HR | p-Value | Multivariable-Adjusted HR † | p-Value |
|---|---|---|---|---|---|---|---|---|
| Overall Survival | ||||||||
| BMI WHO Categories, n (%) | ||||||||
| <18.50 | 2867 | 1617 (56.40) | 1.76 (1.67–1.85) | <0.0001 | 1.68 (1.59–1.77) | <0.0001 | 1.61 (1.53–1.70) | <0.0001 |
| 18.50–24.99 | 23,775 | 9097 (38.26) | Ref. | Ref. | Ref. | |||
| 25.00–29.99 | 11,741 | 3550 (30.24) | 0.75 (0.72–0.78) | <0.0001 | 0.82 (0.79–0.86) | <0.0001 | 0.82 (0.79–0.85) | <0.0001 |
| 30.00–34.99 | 2246 | 655 (29.16) | 0.76 (0.71–0.83) | <0.0001 | 0.87 (0.80–0.94) | <0.0001 | 0.83 (0.77–0.90) | <0.0001 |
| ≥35.00 | 386 | 102 (26.42) | 0.73 (0.60–0.89) | 0.0018 | 0.83 (0.68–1.01) | <0.0001 | 0.74 (0.61–0.90) | 0.0027 |
| CRC-Specific Survival | ||||||||
| BMI WHO Categories, n (%) | ||||||||
| <18.50 | 2867 | 1186 (41.37) | 1.69 (1.59–1.79) | <0.0001 | 1.59 (1.50–1.69) | <0.0001 | 1.52 (1.43–1.62) | <0.0001 |
| 18.50–24.99 | 23,775 | 6911 (29.07) | Ref. | Ref. | Ref. | |||
| 25.00–29.99 | 11,741 | 2696 (22.96) | 0.75 (0.72–0.79) | <0.0001 | 0.85 (0.81–0.88) | <0.0001 | 0.85 (0.81–0.89) | <0.0001 |
| 30.00–34.99 | 2246 | 483 (21.50) | 0.73 (0.66–0.80) | <0.0001 | 0.86 (0.79–0.95) | 0.0015 | 0.85 (0.78–0.94) | 0.0009 |
| ≥35.00 | 386 | 71 (18.39) | 0.64 (0.50–0.80) | 0.0001 | 0.74 (0.59–0.94) | 0.0119 | 0.69 (0.54–0.87) | 0.0017 |
| Disease Free Survival # | ||||||||
| BMI WHO categories, n (%) | ||||||||
| <18.50 | 1853 | 737 (39.77) | 1.73 (1.60–1.87) | <0.0001 | 1.71 (1.58–1.85) | <0.0001 | 1.75 (1.62–1.89) | <0.0001 |
| 18.50–24.99 | 17,660 | 4454 (25.22) | Ref. | Ref. | Ref. | |||
| 25.00–29.99 | 9417 | 1932 (20.52) | 0.81 (0.77–0.85) | <0.0001 | 0.83 (0.78–0.87) | <0.0001 | 0.81 (0.77–0.86) | <0.0001 |
| 30.00–34.99 | 1825 | 381 (20.88) | 0.89 (0.80–0.99) | 0.0329 | 0.94 (0.84–1.04) | 0.2212 | 0.87 (0.79–0.97) | 0.0122 |
| ≥35.00 | 308 | 53 (17.21) | 0.79 (0.60–1.03) | 0.0797 | 0.83 (0.64–1.09) | 0.1852 | 0.75 (0.57–0.98) | 0.0351 |
† Multivariable-adjusted HRs were adjusted for age, gender, stage, grade, cancer site, treatment types, smoking status, and comorbidities. # Excluding 9952 patients whose cancer recurrence were unknown.