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. 2021 Jul 14;10(14):3105. doi: 10.3390/jcm10143105

Table 3.

Comparison of baseline mean scores for routine blood tests among ME/CFS patients based on functional status assessment, illness duration, and case criteria for ME/CFS among participants.

Function Status Illness Duration Case Criteria
Variables
(Mean ± SD)		 Severe
(n = 43)		 Moderate
(n = 75)		 Mild
(n = 31)		 Beta
Eta		 1–2 Years
(n = 14)		 >2 Years
(n = 118)		 Since Childhood
(n = 17)		 Beta
Eta		 Non-ICC (n = 55) ICC
(n = 94)		 Beta
Sedimentation rate
(7.24 ± 4.46)		 6.09 5.88 6.38 0.017
0.045
(ns)		 6.70 6.30 3.92 −0.129
0.184
(ns)		 5.86 6.16 0.039
(ns)
Hemoglobin (13.3 ± 1.17) 13.85 13.89 14.00 0.043
0.055
(ns)		 13.58 13.91 14.09 0.085
0.13
(ns)		 13.90 13.91 −0.002
(ns)
Erythrocytes (4.46 ± 0.43) 4.65 4.63 4.70 0.042
0.084
(ns)		 4.56 4.65 4.67 0.037 0.077
(ns)		 4.65 4.64 −0.011
(ns)
Hematocrit (0.40 ± 0.034) 0.41 0.41 0.42 0.059
0.089
(ns)		 0.40 0.41 0.42 0.076 0.015
(ns)		 0.41 0.41 0.029
(ns)
MCHC (33.45 ± 0.96) 33.65 33.77 33.54 −0.035 0.10
(ns)		 33.81 33.67 33.76 0.009 0.055
(ns)		 33.80 33.61 −0.088
(ns)
MCV (89.47 ± 3.41) 88.90 89.09 89.40 0.050
0.055
(ns)		 88.44 89.11 89.58 0.078 0.077
(ns)		 88.74 89.41 0.098
(ns)
Thrombocytes (242.45 ± 58.26) 248.99 244.11 238.64 −0.057 0.063
(ns)		 230.13 245.27 247.14 0.048 0.077
(ns)		 238.38 248.60 0.08
(ns)
Leukocytes (5.87 ± 1.55) 5.78 5.75 5.52 −0.055 0.063
(ns)		 5.27 5.79 5.56 0.022 0.10 (ns) 5.62 5.78 0.043
(ns)
Lymphocytes (2.05 ± 0.66) 2.09 1.98 1.99 −0.058 0.071
(ns)		 1.72 2.05 1.98 0.081 0.14 (ns) 1.99 2.02 0.027
(ns)
Neutrophils (3.20 ± 1.11) 3.02 3.15 2.87 −0.034 0.10 (ns) 2.89 3.11 2.86 −0.035 0.089
(ns)		 3.02 3.09 0.023
(ns)
Monocytes (0.45 ± 0.15) 0.47 0.45 0.44 −0.052 0.063
(ns)		 0.41 0.46 0.45 0.042 0.089
(ns)		 0.43 0.47 0.14
(ns)
Eosinophils (0.17 ± 0.11) 0.18 0.18 0.18 −0.021 0.032
(ns)		 0.21 0.17 0.20 −0.024 0.122
(ns)		 0.19 0.17 −0.10
(ns)
Basophils (0.029 ± 0.045) 0.034 0.032 0.029 −0.041 0.044
(ns)		 0.028 0.033 0.031 0.004 0.032
(ns)		 0.028 0.035 0.071
(ns)
hsCRP
(1.39 ± 1.86)		 0.82 1.15 1.62 0.15
0.15
(ns)		 1.05 1.27 0.67 −0.045
0.11
(ns)		 1.33 1.032 −0.076
(ns)
Vitamin-B12 (407.74 ± 163) 440.31 386.16 415.44 −0.058
0.14
(ns)		 428.75 405.09 382.37 −0.074 0.063
(ns)		 406.79 402.31 −0.021
(ns)
Vitamin-B9 (19.21 ± 8.89) 20.72 16.94 18.55 −0.10
0.18
(ns)		 19.23 18.53 15.54 −0.12
0.12
(ns)		 18.89 7.64 −0.070
(ns)
Sodium (140.03 ± 2.13) 104.20 140.70 139.95 −0.025
0.15
(ns)		 140.99 140.49 139.63 −0.13
0.15
(ns)		 140.66 140.23 −0.093
(ns)
Potassium (3.77 ± 0.24) 3.76 3.82 3.87 0.16 *
0.17		 4.01 3.80 3.77 −0.21 ** 0.27 ** 3.82 3.81 −0.019
(ns)
P-calcium (2.30 ± 0.075) 2.33 2.32 2.32 −0.087
0.11
(ns)		 2.35 2.32 2.30 −0.14
0.16
(ns)		 2.33 2.31 −0.12
(ns)
S-calcium (1.22 ± 0.034) 1.23 1.22 1.22 −0.060 0.063
(ns)		 1.23 1.22 1.23 0.046
0.11
(ns)		 1.22 1.23 0.076
(ns)
Phosphate (1.03 ± 0.17) 1.042 1.022 1.021 −0.046 0.055
(ns)		 1.078 1.019 1.034 −0.024 0.095
(ns)		 1.019 1.033 0.048
(ns)
ASAT (20.92 ± 5.24) 23.092 22.13 20.51 −0.17 *
0.17		 22.11 22.24 20.67 −0.068 0.095
(ns)		 21.61 22.31 0.065
(ns)
ALAT(21.063 ± 11.67) 26.83 23.031 20.58 −0.19 *
0.20		 21.93 24.17 20.26 −0.067
0.12
(ns)		 22.53 25.097 0.056
(ns)
CK (67.66 ± 34.50) 64.85 87.091 88.34 0.25 *** 0.34 *** 68.41 82.55 88.032 0.11
0.15
(ns)		 87.32 77.75 −0.14
(ns)
Creatinine (65.79 ± 10.75) 68.089 70.81 73.38 0.17 *
0.2		 65.53 71.34 71.14 0.097 *
0.18		 72.90 68.99 −0.18 *
TSH (1.94 ± 0.98) 1.82 1.99 2.16 0.12
0.12
(ns)		 1.66 2.040 1.87 0.041
0.12
(ns)		 2.034 1.94 −0.043
(ns)
Rheumatoid factor-IgA (2.76 ± 2.64) 2.55 2.95 2.41 −0.0090 0.089
(ns)		 2.94 2.58 3.63 0.063
0.12
(ns)		 3.24 2.42 −0.15
(ns)
Rheumatoid factor-IgM (6.12 ± 4.56) 6.12 5.47 6.62 0.028
0.1
(ns)		 5.98 5.79 6.095 0.016
0 (ns)		 6.47 5.42 −0.11
(ns)

Means and t-tests controlled for age, gender, and BMI among the participants. Values are presented as mean ± SD. A significance threshold was set at * p < 0.05, ** p< 0.01, and *** p < 0.001.