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. 2021 Jul 13;9(7):1486. doi: 10.3390/microorganisms9071486

Figure 7.

Figure 7

Effect of Weissella viridescens UCO-SMC3 on the immune response against Cutibacterium acnes skin infection. Mice were divided into three groups: with no UCO-SMC3 treatment (control group); treated topically (108 bacterial cells/mL in sterile PBS on the back) with the UCO-SMC3 strain (cutaneous UCO-SMC3 group) or treated orally (108 bacterial cells/mL in sterile PBS per gavage) with the UCO-SMC3 strain (oral UCO-SMC3 group). W. viridiscens UCO-SMC3 was administered daily for 10 days. On day 11, these mice and the untreated control group were challenged with C. acnes (subdermal injection of 108 CFU). Tumor necrosis factor α (TNF-α), interferon-γ (IFN-γ), and interleukin 1β (IL-1β), IL-4, IL-10, and IL-17 concentrations in serum were determined 5 days after C. acnes infection. Statistically different compared to the infected control group (*) p < 0.05, (**) p < 0.01. Statistically different compared to the non-infected control group (†) p < 0.05, (††) p < 0.01.