Figure 2.

Interruption of the FXN GAA repeat tract is associated with shorter GAA1 repeat sizes and a later age at disease onset. (A) Box-and-whisker plot showing the distribution of the GAA1 repeat sizes for each interruption subgroup of the cohort. Kruskal–Wallis and subsequent Dunn’s multiple comparisons tests show that the 3′ interruption subgroup has significantly smaller GAA1 repeat sizes compared to the subgroup lacking 5′ and 3′ interruptions. Other subgroup comparisons were not significant. (B) Box-and-whisker plot showing the distribution of ages at disease onset across each interruption subgroup of the cohort. Kruskal–Wallis and subsequent Dunn’s multiple comparisons tests show that both the 3′ interruption subgroup and the 5′ and 3′ interruption subgroup have significantly later ages at disease onset compared to the subgroup lacking 5′ and 3′ interruptions. Other subgroup comparisons were not significant. The whiskers indicate the minimum and maximum values whilst the box shows the 25th to 75th percentiles of the data with a line indicating the median. * p ≤ 0.05; *** p ≤ 0.001; **** p ≤ 0.0001.