Table 1.
Mechanisms of RelB action in the central nervous system (CNS).
| Model | Mechanism | Cell Type | Reference |
|---|---|---|---|
| LPS induced tolerance | Epigenetic silencing | Mouse microglia | [99] |
| HIV/Tat induction | Repression of p65 | Mouse microglia | [102] |
| IL-1β induced tolerance | Dimer switching/phosphorylation | Human astrocytes | [47] |
| EAE | Repression of p65 | Mouse oligodendrocytes | [104] |
| miRNA inhibition of CDH7 | Activation of RelB/p50 | Human glioma stem cells | [105] |
| TWEAK induction | Activation of noncanonical pathway (RelB/p52) | Human glioma cells | [106] |
| Overexpression of Eva1 | Activation of noncanonical pathway (RelB/p52) | Human glioma-initiating cells | [107] |
| IL-1 β and OSM stimulation | RelB/p50/YY1 complex formation | Human GBM cells | [108] |